There are a variety of substances that are consumed as drugs which have different origin and composition. Due to differences in the composition, they have different action mechanisms on the brain that may be positive or negative. Among the different structures found in the brain, the synapse is the junction of the exchange of information between two neurons. The drugs will also affect the synapse, which will ultimately affect the communication between neurons and produce abnormal psychological effects. An overdose of drugs will always disturb the body, whereas a low or prescribed amount of drugs works as an agonist. Some drugs and their effects on synapses are:
Nicotine: This is present in the cigarettes in lower amounts (about 2-6mg) and works as an acetylcholine substitute. It activates the nicotine receptors of the autonomic ganglia, adrenal medulla, and neuromuscular junctions. But a high dose of nicotine will lead to blockage of receptors and produce no synaptic transmission.
Pilocarpine: The muscarinic receptors on the post-ganglionic synapse can be activated by a low dose of pilocarpine. It mimics the acetylcholine and enhances its parasympathetic effects, which also helps to reduce intraocular pressure.
Morphine: It belongs to the opiate-drug class that has more post-synaptic effects rather than pre-synaptic effects. Low dose helps in pain relief and cure depression, whereas high doses will block the different receptors leading to blockage of neurotransmission.
Thioridazine: The drug has both positive and negative effects on the synapses. It blocks the dopamine receptors and thus helps to treat psychosis and schizophrenia. Although, it is not specific for receptors and may block other receptors as well that will block synapses and produce Parkinson-like symptoms.
Atropine: This drug is used to treat bradycardia and dilate pupils, but an overdose can cause tachycardia, urine retention, and dry mouth. This is because it affects the postsynaptic membrane by blocking its depolarization by the acetylcholine due to which no impulse is generated.
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