Genomics- an introduction
Genomics is a branch in biology that targets the function, structure, editing, and mapping of the genome. An organismâ€™s entire DNA and of all its genes are known as the genome. This is different from genetics as genetics deals with individual genes along with their inheritance in an organism. Genomics also deals with the analysis and sequencing of the gene through high throughput DNA sequencing and bioinformatics to analyze the structure and functions of the genome. In order to promote knowledge of even the multifaceted biological structures, like the brain, developments in genomics triggered a revolution in discovery-based on science and systems biology. The field also involves studies of the effect of one single gene on more than a single trait (pleiotropy), hybrid vigor effect (heterosis), and the impact of one gene on other genes (epistasis) along with other correlations inside the genome among alleles and loci.
History of gene functions and genomics:
The word genome is derived from the German word Genom by H Winkler. However, the word genomics was first coined by Tom Roderick. Following the discovery of the helical structure of DNA and the publication of its structure in 1953 and the release of the Amino acid sequence present in insulin by Fred Sanger in 1955 took place. The nucleic acid sequencing is a chief focus of former molecular biologists. The first nucleic acid sequence ever identified is the ribonucleotide sequence having alanine transfer RNA (ribonucleic acid) was published by Robert W. Holley and colleagues in 1964. Marshall Nirenberg and Philip Leder discovered the triplet codon existence of the genetic code to expand this research and were able to identify the sequences in their studies of 54 out of 64 codons. In1972, Walter Fiers and his team at the University of Ghent’s Molecular Biology Laboratory (Ghent, Belgium) were the first to determine a gene sequence: the gene for the coat protein Bacteriophage MS2. Types of genomics study- Molecular mechanisms and the interplay of the environmental factors with genetics in disease. Several branches of genomics include:
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