Neurotransmission is the process of traveling information from one neuron to another with the help of neurotransmitters. On the generation of an action potential, the axon terminal releases neurotransmitters into the synapse. The information travels in the form of electric signals and when it reaches the end of the neuron, neurotransmitters are released encapsulated in small sacs. These sacs release neurotransmitters into synapses which go and bind to the receptor-binding region of the next cells and modulate changes in them. The response on cells will depend on the type of neurotransmitter as excitatory, inhibitory, or modulatory. Excitatory neurotransmitters: They encourage the target cells for taking action. They cause depolarization at the postsynaptic cells and generate a fresh action potential. For example acetylcholine. Inhibitory neurotransmitters: These chemicals have a relaxation effect that inhibits the target cells to take any action. For example GABA.
Modulatory neurotransmitters: These neurotransmitters can transmit information to many neurons at the same time. They communicate with other neurotransmitters and interfere with their activities too. For example endorphins.
Major Neurotransmitters And Their Mode of Action
Acetylcholine: It plays a major role in the peripheral nervous system. It triggers muscle contraction, and also control the heartbeat. Acetylcholine is responsible for the proper functioning of the brain and memory collection. The patients of Alzheimerâ€™s disease are found to have a breakdown of acetylcholine. The nutrient choline that forms phospholipids in the body is the building block of acetylcholine. Dopamine: This neurotransmitter is considered as a pleasure or reward neurotransmitter that is related to learning, movement, and coordination in a body. The absence of dopamine is responsible for Parkinson’s disease. Epinephrine: Epinephrine or adrenaline is also called a fight or flight response that increases the heartbeat and also quickens the response. This hormone as well as a neurotransmitter is released in the condition of stress or fear. Epinephrine relaxes the brain functioning and thus a very essential chemical during cardiac arrest and also asthma attacks. Endorphins: They are pain-relieving chemicals that bind to opioid receptors at the presynaptic terminal and act as a euphoric substance. Their binding result in inhibition of tachykinin release that is responsible for the feeling of pain in the body. In the central nervous system, they inhibit the effect of GABA. Thus, they work as a neuromodulator. GABA: Î³ aminobutyric acid (GABA) is a derivative of glutamate, where glutamate is an excitatory neurotransmitter, whereas GABA is an inhibitory one. It is responsible for vision and anxiety regulation. It increases the relaxation in brain cells by inhibitory effects and thus, people suffering from anxiety are treated with benzodiazepines that increase the efficiency of GABA
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