Pregnancy And Estrogen Discussion Essay

From this graph, we can understand that the production of estrogen is started just after the ovulation. We can also observe the static rise in progesterone. hCG and progesterone hormones also play a key role in the maintenance of pregnancy. The level of hormones changes after fertilization; in particular, hCG immediately increases to the highest level at initial pregnancy. However, the levels of estrogen and progesterone slowly increase to stable concentrations, while hCG begins to drop to a certain extent after 3rd trimester of pregnancy. This hCG drop promotes the relaxation of uterine contractions in later gestation.

In human pregnancy, the placenta act as a main source for the production of estrogen in required levels.

Estrogen plays a very important role during pregnancy such as:

Synthesis of progesterone.

Helps in growth of uterus, placenta, blood circulation and another hormone

Progesterone plays a role in the maintenance of the endometrial wall.

Mechanism of placental transfer.

Secretion of placental- trophoblast estrogen, during late gestation

Pigmentation of skin darkening of the nipples, areola and white line that runs down your abdomen

Creation of mask of pregnancy i.e. skin of your forehead, cheek, and nose starts to get tanned.

Extensive vascularisation of the placenta

Initiation in development of fetal ovarian follicular

Beginning of labor

Vascularisation of the placenta and fetal ovarian follicular development continues throughout pregnancy. These events also lead to an increase in placental estrogen biosynthesis.

Estrogen levels during different trimesters of pregnancy:

First Trimester – 187-2498 pg/ml

Second Trimester – 1276-7193 pg/ml

Third Trimester – 6138-3461 pg/

Absence of estrogen & pregnancy
Some scientist believes that if there is a mutation of the estrogen receptor than there is a 50% chance of miscarriage, this shows the importance of estrogen. While others say that pregnancy can be maintained even after the low concentration of estrogen, indicating the non-essentiality of estrogen during pregnancy.But everyone agrees that estrogen has at least two vital roles:

The fetal placental dialogue which helps in the production of progesterone promotes normal development of the fetus, placenta, and adrenal gland. A fetus’s adrenal glands produce cortisol, a steroid hormone that is critical to the maturation of the lungs, liver, and other developing organs and tissues.

A Low level of estrogen will lead to:


Fetuses can die before the miscarriage

Female baby might develop with few eggs

Female babies can face fertility issues.

Lack of vaginal lubrication

Mood swings

Tenderness of breasts


Low level of progesterone hormone

Increased risk of cancer

High risk of obesity

Risk of osteoporosis

High risk of cardiovascular disease

Methods to increase estrogen
Estrogen therapy: This method is efficient for women age between 25 to 50. It is for females who are estrogen-deficient and they are prescribed with a high dose of estrogen. This method helps to increase less risk of cardiovascular disease, bone loss, and imbalance of hormones.

The dosages of the estrogen are prescribed either via injection, orally, vaginally, or tropically. This method helps to reduce the severity of the after-effects of menopause also. Hormone replacement therapy (HRT):

HRT is utilized to expand your body’s normal hormone levels. Your PCP may suggest HRT in case you’re moving toward menopause. Menopause causes your estrogen and progesterone levels to fundamentally diminish. HRT can help return these levels to ordinary. In this treatment, hormones can be regulated:




using infusion

HRT medicines can be balanced in measurements, length, and the blend of hormones. For instance, contingent upon the conclusion, progesterone is frequently utilized related to estrogen.

Ladies moving toward menopause who go through HRT may have an increased danger of cardiovascular illness. The therapy has likewise been appeared to expand your danger of blood coagulating, stroke, and bosom disease.

Natural method:

Here you can enhance your lifestyle, diet, and lose weight to increase your estrogen level.

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