The functional and smallest unit of the kidney is the nephron. At the level of this nephron, much of the study of renal physiology is done. When one considers the structure of a nephron, one can see that each of them starts with a component that filters the blood which is flowing into the kidney. This blood is filtered then traverses across the entire length of the nephron. The nephron is a tubular structure, whose main work is to perform reabsorption of water and other molecules from the filtrate which is passed down to the rest of the structure. This process of reabsorption is facilitated by the layer of special cells which line the insides of the nephron. The wastes which are present in the blood are also removed from the body by passing them through the urine. Thus, the kidneys need to properly function to receive and filter blood adequately.
At the microscopic level, several units of filtration known as the renal corpuscles ensure the proper regulation of the blood filtration system of the kidneys. A glomerulus and a Bowmanâ€™s capsule are the two components of each renal corpuscle. If one estimates the rate of filtration, which is also known as glomerular filtration rate or GFR, then one can get an idea of the renal function and assess it accordingly. Three major significant functions are mediated by the kidney. They are filtration, reabsorption, and secretion. Depending on these three actions, several other functions of the kidneys are also fulfilled. The result that is obtained from the summation of these three components is renal excretion or renal clearance.
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