Glucose is a type of sugar that is present in food and is rich in starch. The body tends to convert carbohydrates present in the food consumed to form glucose. This glucose is then transported to the brain by the blood flow. The regulation of the blood glucose level is referred to as homeostasis. Gluconeogenesis refers to the phenomenon that causes the synthesis of glucose which is mainly required for energy. Glycogen is a storage form of glucose in the liver. Glycogen is responsible for providing extra energy at the time of exercise as well as during fasting. The glycogen present in the liver can last about 18 hours after the meal. The brain, which makes up about 2 percent of our body weight, absorbs about 20 percent of our daily calories. The person who eats the preferred diet wants regular glucose intake – especially those found in freshly consumed carbohydrates (fruits, vegetables, grains, etc.). It is only in the worst cases of depletion that the brain uses other substances as fuel. Newly developed areas of the brain, such as the frontal cortex (similar to the CEO of the brain), are more sensitive to falling glucose levels, while areas of the brain that regulate vital functions are stronger. In contrast, high levels of sugar are slowly but surely damaging to cells everywhere in the body, including those in the brain. The bodyâ€™s immune response, which occurs regardless of weight gain, can cause cognitive deficits similar to those associated with Alzheimerâ€™s disease. Similarly, high blood sugar, which is associated with cognitive function, is associated with higher cortisol – a hormone known to impair memory at high levels. The above figure shows that the major form of energy is glucose for the brains of mammals. The significant centers of the brain, which includes proopiomelanocortin present within the hypothalamus have moderate glucose levels. Glucose metabolism is maintained by vagal nerve and neuroendocrine signals. Blood carries the glucose to the brain via the blood-brain barrier using a glucose transporter. The other metabolites and glucose are responsible for providing neurotransmission and together responsible for regulating the survival of the cell. Disruption of the metabolism of glucose is the main reason for the development of brain disease.
Glucose on Brain Functioning
Without complex regulation, short-term induction of glucose uptake occurs in certain areas of the brain. Several studies demonstrate that how glucose is responsible for improving mental conditions, especially regarding memory and concentration. one of the studies said that glucose drink significantly improved long-term voice memory and adult memory. Another research found the improved memory by glucose uptake. Brain functions are highly dependent on glucose uptake from their simple activities to the complex ones. The brain acts sensitively if the level of glucose decreases in the blood. A good level of glucose improves the activity of the brain, and in contrast, a low glucose level can affect its normal functioning.
The Energy Requirement of the Brain
The human brain is primarily made up of a network of neurons that functions while the body is asleep. Getting the proper energy to support their function brain has to look for the glucose in the blood continuously. An average weighted adult needs to consume 200 g of glucose per day from which 130 g of glucose is needed for the healthy activity of the brain. The brain has to struggle to absorb glucose from the blood when the concentration of glucose is low, just like the rest of the body. This condition arises at the time of starvation. Glucose is necessary for regulating brain activity, and two mechanisms maintain it-
One involves injecting the glucose in the blood in weakness when cells are not able to produce glucose.
Second, involved decreasing the amount of glucose for the rest of the body and primarily making it available for the brain. These mechanisms of insurance are survival.
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